Journal article icon

Journal article

Comparing ion-pairing reagents and sample dissolution solvents for ion-pairing reversed-phase liquid chromatography/electrospray ionization mass spectrometry analysis of oligonucleotides.

Abstract:

RATIONALE: A sensitive and selective liquid chromatography/mass spectrometry (LC/MS) method is essential for quality control of synthetic oligonucleotides. However, researchers are still searching for improvements to ion-pairing reagents for ion-pairing reversed-phase LC/MS. This study performed a comprehensive comparison of six ion-pairing reagents to determine their performance as mobile phase modifiers for oligonucleotide LC/MS. METHODS: The study was performed using a Waters ultra-perform...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/rcm.6773

Authors


McCullagh, JS More by this author
Journal:
Rapid communications in mass spectrometry : RCM
Volume:
28
Issue:
4
Pages:
339-350
Publication date:
2014-02-05
DOI:
EISSN:
1097-0231
ISSN:
0951-4198
URN:
uuid:e1e221fa-60d8-464c-a165-41cfdf5065ca
Source identifiers:
447316
Local pid:
pubs:447316

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP