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The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary.

Abstract:

The short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein superfamilies known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobiotics. We have currently identified 73 SDR superfamily members within the human genome. A status report of the human SDR superfamily is provided in terms of 3D structure determination, co-factor pre...

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Publication status:
Published

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Publisher copy:
10.1016/j.cbi.2008.10.058

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Chemico-biological interactions
Volume:
178
Issue:
1-3
Pages:
99-109
Publication date:
2009-03-05
DOI:
EISSN:
1872-7786
ISSN:
0009-2797
URN:
uuid:e1c93cc9-1b18-4e74-b766-edd0614b9067
Source identifiers:
54088
Local pid:
pubs:54088

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