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Combining organometallic reagents, the sulfur dioxide surrogate DABSO, and amines: a one-pot preparation of sulfonamides, amenable to array synthesis.

Abstract:

We describe a method for the synthesis of sulfonamides through the combination of an organometallic reagent, a sulfur dioxide equivalent, and an aqueous solution of an amine under oxidative conditions (bleach). This simple reaction protocol avoids the need to employ sulfonyl chloride substrates, thus removing the limitation imposed by the commercial availability of these reagents. The resultant method allows access to new chemical space, and is also tolerant of the polar functional groups nee...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/anie.201409283

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Engineering and Physical Sciences Research Council More from this funder
Publisher:
Wiley-VCH Publisher's website
Journal:
Angewandte Chemie (International ed. in English) Journal website
Volume:
54
Issue:
4
Pages:
1168-1171
Publication date:
2015-01-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:e1abe2aa-c348-43ef-a4b5-33608905eff3
Source identifiers:
491887
Local pid:
pubs:491887

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