Journal article
Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids
- Abstract:
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This paper explores the computer modelling aided design and synthesis of β-N-acetylhexosaminidase inhibitors along with their applicability to human disease treatment through biological evaluation in both an enzymatic and cellular setting. We investigated the importance of individual stereocenters, variations in structure-activity relationships along with factors influencing cell penetration. To achieve these goals we modified nitrogen heterocycles in terms of ring size, side chains present a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1039/c6ob01549b
Authors
Funding
Bibliographic Details
- Publisher:
- Royal Society of Chemistry
- Journal:
- Organic & Biomolecular Chemistry More from this journal
- Volume:
- 14
- Issue:
- 44
- Pages:
- 10371-10385
- Publication date:
- 2016-10-06
- Acceptance date:
- 2016-10-06
- DOI:
- EISSN:
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1477-0539
- ISSN:
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1477-0520
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:653196
- UUID:
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uuid:e1a8926c-936b-4abc-ab44-f4245de64426
- Local pid:
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pubs:653196
- Source identifiers:
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653196
- Deposit date:
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2016-11-01
Terms of use
- Copyright holder:
- © The Royal Society of Chemistry 2016
- Copyright date:
- 2016
- Notes:
- © The Royal Society of Chemistry 2016. This is the author accepted manuscript following peer review version of the article. The final version is available online from Royal Society of Chemistry at: 10.1039/c6ob01549b
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