Journal article
DNA-protein crosslink proteolysis repair
- Abstract:
- Proteins that are covalently bound to DNA constitute a specific type of DNA lesion known as DNA-protein crosslinks (DPCs). DPCs represent physical obstacles to the progression of DNA replication. If not repaired, DPCs cause stalling of DNA replication forks that consequently leads to DNA double-strand breaks, the most cytotoxic DNA lesion. Although DPCs are common DNA lesions, the mechanism of DPC repair was unclear until now. Recent work unveiled that DPC repair is orchestrated by proteolysis performed by two distinct metalloproteases, SPARTAN in metazoans and Wss1 in yeast. This review summarizes recent discoveries on two proteases in DNA replication-coupled DPC repair and establishes DPC proteolysis repair as a separate DNA repair pathway for genome stability and protection from accelerated aging and cancer.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 2.3MB, Terms of use)
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- Publisher copy:
- 10.1016/j.tibs.2017.03.005
Authors
- Publisher:
- Elsevier
- Journal:
- Trends in Biochemical Sciences More from this journal
- Volume:
- 42
- Issue:
- 6
- Pages:
- 483-495
- Publication date:
- 2017-03-20
- Acceptance date:
- 2017-04-14
- DOI:
- EISSN:
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0167-7640
- ISSN:
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0968-0004
- Pmid:
-
28416269
- Language:
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English
- Keywords:
- Pubs id:
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pubs:691196
- UUID:
-
uuid:e18beb37-e088-410a-ae8b-3299e1456de3
- Local pid:
-
pubs:691196
- Source identifiers:
-
691196
- Deposit date:
-
2019-08-30
Terms of use
- Copyright date:
- 2017
- Notes:
- This is an author version of the article. The final version is available online from the publisher’s website
- Licence:
- CC Attribution (CC BY)
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