Journal article
Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India
- Abstract:
- Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. Understanding the genetic epidemiology of XDR-Kp can help determine its potential to be hypervirulent (hv) through the presence of siderophores. We characterized the genomes of 18 colistin-resistant XDR-Kp isolated from 14 patients with complicated tract infection at an Indian healthcare facility. The 18 organisms comprised the following sequence types (STs): ST14 (n = 9), ST147 (n = 5), ST231 (n = 2), ST2096 (n = 1), and ST25 (n = 1). Many patients in each ward were infected with the same ST, suggesting a common source of infection. Some patients had recurrent infections with multiple STs circulating in the ward, providing evidence of hospital transmission. β-lactamase genes (blaCTX-M-1, blaSHV, and blaampH) were present in all isolates. blaNDM-1 was present in 15 isolates, blaOXA-1 in 16 isolates, blaTEM-1D in 13 isolates, and blaOXA-48 in 3 isolates. Disruption of mgrB by various insertion sequences was responsible for colistin resistance in 6 isolates. The most common K-type among isolates was K2 (n = 10). One XDR convergent hvKp ST2096 mutation (iuc+ybt+blaOXA-1+blaOXA-48) was associated with prolonged hospitalization. Convergent XDR-hvKp has outbreak potential, warranting effective antimicrobial stewardship and infection control.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.6MB, Terms of use)
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- Publisher copy:
- 10.7883/yoken.jjid.2023.009
Authors
- Publisher:
- National Institute of Infectious Diseases
- Journal:
- Japanese Journal of Infectious Diseases More from this journal
- Volume:
- 77
- Issue:
- 1
- Pages:
- 7-15
- Place of publication:
- Japan
- Publication date:
- 2023-08-31
- Acceptance date:
- 2023-08-08
- DOI:
- EISSN:
-
1884-2836
- ISSN:
-
1344-6304
- Pmid:
-
37648492
- Language:
-
English
- Keywords:
- Pubs id:
-
1518451
- Local pid:
-
pubs:1518451
- Deposit date:
-
2025-01-14
Terms of use
- Copyright holder:
- Kaza et al
- Copyright date:
- 2023
- Rights statement:
- ©2023 The Authors. This paper is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
- Licence:
- CC Attribution (CC BY)
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