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Coupling form and function: how the oligomerisation symmetry of the SAS-6 protein contributes to the architecture of centriole organelles

Abstract:

Centrioles make up the centrosome and basal bodies in animals and as such play important roles in cell division, signalling and motility. They possess characteristic 9-fold radial symmetry strongly influenced by the protein SAS-6. SAS-6 is essential for canonical centriole assembly as it forms the central core of the organelle, which is then surrounded by microtubules. SAS-6 self-assembles into an oligomer with elongated spokes that emanate towards the outer microtubule wall; in this manne...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3390/sym9050074

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Lincoln College
Publisher:
Multidisciplinary Digital Publishing Institute Publisher's website
Journal:
Symmetry Journal website
Volume:
9
Issue:
5
Pages:
Article: 74
Publication date:
2017-05-16
Acceptance date:
2017-05-12
DOI:
ISSN:
2073-8994
Pubs id:
pubs:701505
URN:
uri:e14edc0a-d09c-4008-9e65-6086859a9f47
UUID:
uuid:e14edc0a-d09c-4008-9e65-6086859a9f47
Local pid:
pubs:701505

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