Journal article
Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes
- Abstract:
-
Background: The TNF/LTA locus has been a long-standing T2D candidate gene. Several studies have examined association of TNF/LTA SNPs with T2D but the majority have been small-scale and produced no convincing evidence of association. The purpose of this study is to examine T2D association of tag SNPs in the TNF/LTA region capturing the majority of common variation in a large-scale sample set of UK/Irish origin.
Methods: This study comprised a case-control (1520 cases and 2570 control samples) and a family-based component (423 parent-offspring trios). Eleven tag SNPs (rs928815, rs909253, rs746868, rs1041981 (T60N), rs1800750, rs1800629 (G-308A), rs361525 (G-238A), rs3093662, rs3093664, rs3093665, and rs3093668) were selected across the TNF/LTA locus and genotyped using a fluorescence-based competitive allele specific assay. Quality control of the obtained genotypes was performed prior to single- and multi-point association analyses under the additive model.
Results: We did not find any consistent SNP associations with T2D in the case-control or family-based datasets.
Conclusions: The present study, designed to analyse a set of tag SNPs specifically selected to capture the majority of common variation in the TNF/LTA gene region, found no robust evidence for association with T2D. To investigate the presence of smaller effects of TNF/LTA gene variation with T2D, a large-scale meta-analysis will be required.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 754.9KB, Terms of use)
-
- Publisher copy:
- 10.1186/1471-2350-11-69
Authors
- Publisher:
- BioMed Central
- Journal:
- BMC Medical Genetics More from this journal
- Volume:
- 11
- Article number:
- 69
- Publication date:
- 2010-05-06
- Acceptance date:
- 2010-05-06
- DOI:
- EISSN:
-
1471-2350
- Language:
-
English
- Keywords:
- UUID:
-
uuid:e0d495ee-393a-4326-91ef-747378a99443
- Local pid:
-
pubs:60599
- Source identifiers:
-
60599
- Deposit date:
-
2012-12-19
Terms of use
- Copyright holder:
- Boraska et al
- Copyright date:
- 2010
- Notes:
- © 2010 Boraska et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record