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The role of human innate immune factors in nasal colonization by Staphylococcus aureus.

Abstract:

Staphylococcus aureus colonization of the human nares predisposes to sometimes severe auto-infection. To investigate whether genetic polymorphism affects the S. aureus carriage status, sequence variation in alpha-defensin and beta-defensin, and mannose-binding lectin (MBL) genes were determined for a group of volunteers (n=109) with known S. aureus nasal carriage status. DEFA1/3 expression was measured in a subset of the volunteers (n=32). None of the single nucleotide polymorphisms studied c...

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Publication status:
Published

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Authors


van Belkum, A More by this author
Wertheim, H More by this author
de Jongh, C More by this author
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Journal:
Microbes and infection / Institut Pasteur
Volume:
9
Issue:
12-13
Pages:
1471-1477
Publication date:
2007-10-05
DOI:
EISSN:
1769-714X
ISSN:
1286-4579
URN:
uuid:e0b42608-eb69-4aca-8d55-a5686cd5ba23
Source identifiers:
67977
Local pid:
pubs:67977

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