Journal article icon

Journal article

Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.

Abstract:

Vitamin B(12) (cobalamin, Cbl) is essential to the function of two human enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MUT). The conversion of dietary Cbl to its cofactor forms, methyl-Cbl (MeCbl) for MS and adenosyl-Cbl (AdoCbl) for MUT, located in the cytosol and mitochondria, respectively, requires a complex pathway of intracellular processing and trafficking. One of the processing proteins, MMAA (methylmalonic aciduria type A), is implicated in the mitochondrial assembly...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m110.177717

Authors


Expand authors...
Journal:
The Journal of biological chemistry
Volume:
285
Issue:
49
Pages:
38204-38213
Publication date:
2010-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:e0b2bc2d-8ba8-40a8-9d1e-19a0c63a4731
Source identifiers:
108861
Local pid:
pubs:108861

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP