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Journal article

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.

Abstract:

Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT cells are activated by a broad range of bacteria through detection of riboflavin metabolites bound by MR1, but their direct cytolytic capacity upon recognition of cognate target cells remains unclear. We show that resting human MAIT cells are uniquely characterized by a lack of granzyme (Gr) B and low perforin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/mi.2014.81

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Peter Medawar Building for Pathogen Research
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Peter Medawar Building for Pathogen Research
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Peter Medawar Building for Pathogen Research
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
Role:
Author
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Medical Research Council More from this funder
NIHR Biomedical Research Centre More from this funder
Nuffield Department of Clinical Medicine More from this funder
James Martin School for the 21st Century More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Mucosal immunology Journal website
Volume:
8
Issue:
2
Pages:
429-440
Publication date:
2015-03-05
DOI:
EISSN:
1935-3456
ISSN:
1933-0219
URN:
uuid:e0ad37a0-5ee4-4bdb-9e10-b61ff9c85e29
Source identifiers:
485847
Local pid:
pubs:485847
Language:
English

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