Journal article

Synthetic tools for studying the chemical biology of InsP8

Abstract:: To synthesise stabilised mimics of InsP₈, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP₈ metabolism.

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Riley, A., Wang, H., Shears, S., & Potter, B. (2015). Synthetic tools for studying the chemical biology of InsP8. Chemical Communications, 51, 12605–12608.

MLA Style

Riley, A, et al. “Synthetic Tools for Studying the Chemical Biology of InsP8.” Chemical Communications, vol. 51, 2015, pp. 12605–08.

Chicago Style

Riley, A, H Wang, S Shears, and B Potter. 2015. “Synthetic Tools for Studying the Chemical Biology of InsP8.” Chemical Communications 51: 12605–8.
Print

Access Document

Files:: Supplementary information.pdf

(Preview, pdf, 4.2MB, Terms of use)

Synthetic tools for studying the chemical biology of InsP8.pdf

(Preview, pdf, 2.0MB, Terms of use)

Publisher copy:: 10.1039/C5CC05017K

Publication website:: http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC05017K#!divAbstract

Authors

+ Riley, A More by this author

Department:: University of Bath
Role:: Author

+ Wang, H More by this author

Department:: National Institutes of Health
Role:: Author

+ Shears, S More by this author

Department:: National Institutes of Health
Role:: Author

+ Potter, B More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Pharmacology
Role:: Author

+ NIH/National Institute of Environmental Health Sciences More from this funder

Publisher:: Royal Society of Chemistry
Journal:: Chemical Communications More from this journal
Volume:: 51
Pages:: 12605-12608
Publication date:: 2015-07-03
Acceptance date:: 2015-07-03
DOI:: 10.1039/C5CC05017K
EISSN:: 1364-548X
ISSN:: 1359-7345

Language:: English
UUID:: uuid:e0a9a93a-753f-417d-8fbb-445da8c6009d
Deposit date:: 2015-07-23
ARK identifier:: ark:/29072/ora_e0a9a93a753f417d8fbb445da8c6009d

Terms of use

Copyright date:: 2015

Licence:: CC Attribution (CC BY)

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP