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Synthetic tools for studying the chemical biology of InsP8

Abstract:
To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/C5CC05017K

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Department:
University of Bath
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Department:
National Institutes of Health
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Department:
National Institutes of Health
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Department:
Pharmacology, University of Oxford
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communications
Volume:
51
Pages:
12605-12608
Publication date:
2015-03-07
Acceptance date:
2015-03-07
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Language:
English

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