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Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.

Abstract:

The magnitude of the obesity and metabolic syndrome epidemic has heightened the need for the development of new and effective treatments. Although circulating cortisol concentrations are not elevated in obesity or in the metabolic syndrome, decreasing the tissue-specific generation of cortisol through inhibition of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) has been postulated as a therapeutic strategy. Observations in cohorts of obese patients, in comparison with those with typ...

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Publication status:
Published

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Publisher copy:
10.1038/ncpendmet0023

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Role:
Author
Journal:
Nature clinical practice. Endocrinology and metabolism
Volume:
1
Issue:
2
Pages:
92-99
Publication date:
2005-12-05
DOI:
EISSN:
1745-8374
ISSN:
1745-8366
URN:
uuid:e0a5e9b7-5097-4e6d-9418-a5cadd1363cc
Source identifiers:
482100
Local pid:
pubs:482100

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