Long-range correlations in the mechanics of small DNA circles under topological stress revealed by multi-scale simulation
It is well established that gene regulation can be achieved through activator and repressor proteins that bind to DNA and switch particular genes on or off, and that complex metabolic networks determine the levels of transcription of a given gene at a given time. Using three complementary computational techniques to study the sequence-dependence of DNA denaturation within DNA minicircles, we have observed that whenever the ends of the DNA are constrained, information can be transferred over l...Expand abstract
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Copyright © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
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