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Journal article

Long-range correlations in the mechanics of small DNA circles under topological stress revealed by multi-scale simulation

Abstract:

It is well established that gene regulation can be achieved through activator and repressor proteins that bind to DNA and switch particular genes on or off, and that complex metabolic networks determine the levels of transcription of a given gene at a given time. Using three complementary computational techniques to study the sequence-dependence of DNA denaturation within DNA minicircles, we have observed that whenever the ends of the DNA are constrained, information can be transferred over l...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkw815

Authors


Sutthibutpong, T More by this author
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
44
Issue:
19
Pages:
9121-9130
Publication date:
2016-09-22
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:647771
URN:
uri:e094ea1e-1bb7-4804-bb07-e64667f799ba
UUID:
uuid:e094ea1e-1bb7-4804-bb07-e64667f799ba
Local pid:
pubs:647771
Language:
English
Keywords:

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