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Journal article

Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche

Abstract:

Runx1 is an important haematopoietic transcription factor as stressed by its involvement in a number of haematological malignancies. Furthermore, it is a key regulator of the emergence of the first haematopoietic stem cells (HSCs) during development. The transcription factor Gata3 has also been linked to haematological disease and was shown to promote HSC production in the embryo by inducing the secretion of important niche factors. Both proteins are expressed in several different cell types ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1002/iub.2184

Authors


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Kay Kendall Leukaemia Fund More from this funder
Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Wiley Publisher's website
Journal:
IUBMB Life Journal website
Volume:
72
Issue:
1
Pages:
45-52
Publication date:
2019-10-21
Acceptance date:
2019-10-01
DOI:
EISSN:
1521-6551
ISSN:
1521-6543
Pmid:
31634421
Pubs id:
pubs:1071928
UUID:
uuid:e0899ddd-06d9-42ff-9531-1ca1c61c4279
Source identifiers:
1071928
Local pid:
pubs:1071928

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