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QuantiFERON conversion following tuberculin administration is common in HIV infection and relates to baseline response.

Abstract:

Background

HIV-1 infection impairs tuberculosis (TB) specific immune responses affecting the diagnosis of latent TB. We aimed to (1) determine the proportion of HIV-1-infected adults with a negative QuantiFERON®-TB Gold in-tube (QFT-GIT) and Tuberculin skin testing (TST) that convert to QFT-GIT positive following TST, and (2) evaluate the relationship between conversion and baseline QFT-GIT results.

Methods

HIV-1 infected adults being screened for a TB vaccine stu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12879-016-1875-6

Authors


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Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
BMC Infectious Diseases Journal website
Volume:
16
Issue:
1
Pages:
545
Publication date:
2016-10-05
Acceptance date:
2016-09-27
DOI:
ISSN:
1471-2334
Pubs id:
pubs:652354
URN:
uri:e06df011-b35e-43b6-be7b-acefffec800a
UUID:
uuid:e06df011-b35e-43b6-be7b-acefffec800a
Local pid:
pubs:652354

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