INTENSIVE INTRAVENOUS REGIMEN FOR SEVERE ATTACKS OF ULCERATIVE COLITIS

Journal article

A 5-day intensive intravenous regimen for the treatment of severe attacks of ulcerative colitis has been developed, and the results in forty-nine patients treated in this way in a 5-year period are described. Thirty-six patients were in complete remission at the end of the 5-day course. Four showed clinical improvement without remission, and they all required urgent surgery within the next 6 weeks. The remainder were unchanged by the intravenous regimen and required emergency surgery. This regimen gives a higher remission-rate than has been recorded previously, and failure to respond provides a simple and straightforward indication for surgery without further delay. When used in the treatment of first attacks of the disease, the regimen gives a considerable chance of a prolonged remission. Two-thirds of the first-attack patients who went into remission remained symptom-free during the period of follow-up, which averaged more than 3 years. © 1974.

Authors: Truelove, S; Jewell, D

• Journal: Lancet
• Volume: 303
• Issue: 7866
• Pages: 1067-1070
• Publication date: 1974-06-01
• DOI: 10.1016/S0140-6736(74)90552-2
• ISSN: 0140-6736
• Language: English