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Journal article

Structure and function of the PP2A-shugoshin interaction.

Abstract:

Accurate chromosome segregation during mitosis and meiosis depends on shugoshin proteins that prevent precocious dissociation of cohesin from centromeres. Shugoshins associate with PP2A, which is thought to dephosphorylate cohesin and thereby prevent cleavage by separase during meiosis I. A crystal structure of a complex between a fragment of human Sgo1 and an AB'C PP2A holoenzyme reveals that Sgo1 forms a homodimeric parallel coiled coil that docks simultaneously onto PP2A's C and B' subunit...

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Publication status:
Published

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Journal:
Molecular cell
Volume:
35
Issue:
4
Pages:
426-441
Publication date:
2009-08-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:e027be12-b1ec-40c1-98d5-ae77d0b3810c
Source identifiers:
5055
Local pid:
pubs:5055

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