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Glucose homeostasis in mice is transglutaminase 2 independent

Abstract:

Transglutaminase type 2 (TG2) has been reported to be a candidate gene for maturity onset diabetes of the young (MODY) because three different mutations that impair TG2 transamidase activity have been found in 3 families with MODY. TG2 null (TG2(-/-)) mice have been reported to be glucose intolerant and have impaired glucose-stimulated insulin secretion (GSIS). Here we rigorously evaluated the role of TG2 in glucose metabolism using independently generated murine models of genetic TG2 disrupt...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0063346

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
8
Issue:
5
Pages:
e63346
Publication date:
2013-05-22
Acceptance date:
2013-03-29
DOI:
EISSN:
1932-6203
URN:
uuid:e02653ac-842c-416e-bc35-d974cb435d9f
Source identifiers:
402276
Local pid:
pubs:402276

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