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Journal article

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

Abstract:

Inflammasomes are protein platforms linking recognition of microbe, pathogen-associated and damage-associated molecular patterns by cytosolic sensory proteins to caspase-1 activation. Caspase-1 promotes pyroptotic cell death and the maturation and secretion of interleukin (IL)-1β and IL-18, which trigger inflammatory responses to clear infections and initiate wound-healing; however, excessive responses cause inflammatory disease. Inflammasome assembly requires the PYRIN domain (PYD)-containin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms15556

Authors


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Vietnam Education Foundation More from this funder
American Heart Association More from this funder
Arthritis Foundation More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
15556
Publication date:
2017-06-05
Acceptance date:
2017-04-07
DOI:
EISSN:
2041-1723
Pubs id:
pubs:700837
URN:
uri:e00aaa9e-c18d-478d-b249-8d8cbeba1f3c
UUID:
uuid:e00aaa9e-c18d-478d-b249-8d8cbeba1f3c
Local pid:
pubs:700837
Language:
English
Keywords:

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