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Comparison of cellular responses to TGF-β1 and BMP-2 between healthy and torn tendons

Abstract:

Background: Tendons heal by fibrotic repair, increasing the likelihood of reinjury. Animal tendon injury and overuse models have identified transforming growth factor beta (TGF-β) and bone morphogenetic proteins (BMPs) as growth factors actively involved in the development of fibrosis, by mediating extracellular matrix synthesis and cell differentiation.

Purpose: To understand how TGF-β and BMPs contribute to fibrotic processes using tendon-derived...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/03635465211011158

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Research group:
NIHR Oxford Biomedical Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Research group:
NIHR Oxford Biomedical Research Centre
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0002-7052-3793
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Research group:
NIHR Oxford Biomedical Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Research group:
NIHR Oxford Biomedical Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Research group:
NIHR Oxford Biomedical Research Centre
Role:
Author
More from this funder
Name:
Versus Arthritis
Grant:
22425
Publisher:
SAGE Publications
Journal:
American Journal of Sports Medicine More from this journal
Volume:
49
Issue:
7
Pages:
1892-1903
Publication date:
2021-06-01
Acceptance date:
2021-01-04
DOI:
EISSN:
1552-3365
ISSN:
0363-5465
Pmid:
34081556

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