Immunization of HIV-infected adults in the UK with Haemophilus influenzae b/meningococcal C glycoconjugate and pneumococcal polysaccharide vaccines

Journal article

U.K. guidelines for vaccinating HIV-infected adults against bacteria are based on limited data. We compared antibody responses between 211 HIV-infected and 73 HIV-uninfected adults vaccinated with pneumococcal polysaccharide vaccine (PPV) and Haemophilus influenzae b/meningococcal C polysaccharide-tetanus toxoid glycoconjugate vaccine (Hib/MenC-TT). IgG responses to Hib/MenC-TT were not significantly different. PPV induced median IgGs >1.3 μg/mL for 10/12 serotypes among HIV-uninfected participants and 5/12 in HIV-infected participants. HIV-uninfected adults had higher post-vaccination IgGs than HIV-infected adults for 4/12 serotypes (P < 0.001). Responses did not associate with CD4 count or viral suppression. In a U.K. HIV-infected population, Hib/MenC-TT induced similar responses to HIV-uninfected adults, whereas PPV induced poor responses.

Authors: MacLennan, C; Richter, A; Hodson, J; Faustini, S; Birtwistle, J

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Lippincott, Williams and Wilkins
• Journal: Journal of Acquired Immune Deficiency Syndromes
• Volume: 73
• Issue: 3
• Pages: 287–293
• Publication date: 2016-11-01
• Acceptance date: 2016-04-04
• DOI: 10.1097/QAI.0000000000001054
• EISSN: 1944-7884
• ISSN: 1525-4135
• Language: English
• Keywords: vaccines; bacteria; meningococcus; HIV; Haemophilus influenzae b; pneumococcus