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Journal article

Measurement of myofilament-localised calcium dynamics in adult cardiomyocytes and the effect of hypertrophic cardiomyopathy mutations

Abstract:

Rationale: Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mutation, or small molecules may alter contractility through myofilament Ca2+ sensitivity. Here we develop and characterise genetically encoded Ca2+ indicators restricted to the myofilament to directly visualise Ca2 changes in the sarcomere.

Objective: To produce and validate myofilament restricted Ca2+ imaging probes in an adenoviral transduction adult...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1161/circresaha.118.314600

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Cardiovascular Medicine
Sievert, K More by this author
Chang, Y-F More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
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Publisher:
American Heart Association Publisher's website
Journal:
Circulation Research Journal website
Volume:
124
Issue:
8
Pages:
1228–1239
Publication date:
2019-02-08
Acceptance date:
2019-02-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Pubs id:
pubs:969431
URN:
uri:dfd004fd-2311-4286-abd6-123e14e33d79
UUID:
uuid:dfd004fd-2311-4286-abd6-123e14e33d79
Local pid:
pubs:969431

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