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Journal article

Transcriptional regulator PRDM12 is essential for human pain perception

Abstract:

Pain perception has evolved as a warning mechanism to alert organisms to tissue damage and dangerous environments1,2. In humans, however, undesirable, excessive or chronic pain is a common and major societal burden for which available medical treatments are currently suboptimal3,4. New therapeutic options have recently been derived from studies of individuals with congenital insensitivity to pain (CIP)5,6. Here we identified 10 different homozygous mutations in PRDM12 (encoding PRDI-BF1 and R...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/ng.3308

Authors


Auer-Grumbach, M More by this author
Matsukawa, S More by this author
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Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Department:
Oxford, MSD, Clinical Neurosciences
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Publisher:
Nature Research Publisher's website
Journal:
Nature genetics Journal website
Volume:
47
Issue:
7
Pages:
803-808
Publication date:
2015-07-17
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:525621
URN:
uri:dfb73a9b-0ac0-411e-91ac-928e4fd270a2
UUID:
uuid:dfb73a9b-0ac0-411e-91ac-928e4fd270a2
Local pid:
pubs:525621
Language:
English
Keywords:

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