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Exploiting carbonyl groups to control intermolecular rhodium-catalyzed alkene and alkyne hydroacylation

Abstract:

Readily available β-carbonyl-substituted aldehydes are shown to be exceptional substrates for Rh-catalyzed intermolecular alkene and alkyne hydroacylation reactions. By using cationic rhodium catalysts incorporating bis-phosphine ligands efficient and selective reactions are achieved for β-amido, β-ester and β-keto aldehyde substrates, providing a range of synthetically useful 1,3-dicarbonyl products in excellent yields. A correspondingly broad selection of alkenes and alkynes can ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
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Publisher copy:
10.1021/jacs.7b05713

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
139
Issue:
29
Pages:
10142–10149
Publication date:
2017-07-17
Acceptance date:
2017-06-30
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pubs id:
pubs:702712
URN:
uri:df9ab9b4-9608-45ad-98e5-4bd051f2ed8b
UUID:
uuid:df9ab9b4-9608-45ad-98e5-4bd051f2ed8b
Local pid:
pubs:702712

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