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Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau.

Abstract:

Tau is a highly abundant and multifunctional brain protein that accumulates in neurofibrillary tangles (NFTs), most commonly in Alzheimer's disease (AD) and primary age-related tauopathy. Recently, microRNAs (miRNAs) have been linked to neurodegeneration; however, it is not clear whether miRNA dysregulation contributes to tau neurotoxicity. Here, we determined that the highly conserved brain miRNA miR-219 is downregulated in brain tissue taken at autopsy from patients with AD and from those w...

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Publisher copy:
10.1172/jci78421

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
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Journal:
The Journal of clinical investigation
Volume:
125
Issue:
2
Pages:
681-686
Publication date:
2015-02-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:df9a8da5-901f-4554-9383-7c4f199c6772
Source identifiers:
504423
Local pid:
pubs:504423
Language:
English

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