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Journal article

Genetic variants in ERAP1 and ERAP2 associated with immune-mediated diseases influence protein expression and the isoform profile

Abstract:

Objective

Endoplasmic reticulum aminopeptidase 1 (ERAP‐1) and ERAP‐2, encoded on chromosome 5q15, trim endogenous peptides for HLA‐mediated presentation to the immune system. Polymorphisms in ERAP1 and/or ERAP2 are strongly associated with several immune‐mediated diseases with specific HLA backgrounds, implicating altered peptide handling and presentation as prerequisites for autoreactivity against an arthritogenic peptide. Given the thorough characterization of disease risk–asso...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/art.40369

Authors


Hanson, AL More by this author
Cuddihy, T More by this author
Morton, CJ More by this author
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Queensland Government More from this funder
National Health and Medical Research Council More from this funder
Arthritis Research UK More from this funder
Publisher:
Wiley Publisher's website
Journal:
Arthritis and Rheumatology Journal website
Volume:
70
Issue:
2
Pages:
255-265
Publication date:
2017-11-06
Acceptance date:
2017-10-26
DOI:
EISSN:
2326-5205
ISSN:
2326-5191
Pubs id:
pubs:745964
URN:
uri:df896fb4-817b-419a-84a7-b139ace596b7
UUID:
uuid:df896fb4-817b-419a-84a7-b139ace596b7
Local pid:
pubs:745964
Language:
English
Keywords:

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