- Abstract:
-
We have used oligonucleotides containing appropriately placed fluorophores and quenchers to measure the stability of 15mer intermolecular triplexes with third strands consisting of repeats of TTT, TTC, TCC and TCTC. In the presence of 200 mM sodium (pH 5.0) triplexes that contain only T.AT triplets are unstable and melt below 30 degrees C. In contrast, triplets with repeats of TTC, TCC and CTCT melt at 67, 72 and 76 degrees C, respectively. The most stable complex is generated by the sequence...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/nar/gkg782
-
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- Journal:
- Nucleic acids research
- Volume:
- 31
- Issue:
- 19
- Pages:
- 5598-5606
- Publication date:
- 2003-10-05
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:df649fc0-2440-4f7c-99d2-8830a1091533
- Source identifiers:
-
400054
- Local pid:
- pubs:400054
- Copyright date:
- 2003
Journal article
Thermodynamic and kinetic stability of intermolecular triple helices containing different proportions of C+*GC and T*AT triplets.
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