Journal article
HLA variation and disease
- Abstract:
- Fifty years since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing autoimmune reactivity. Technological advances have enabled pivotal progress in the determination of the molecular mechanisms that underpin the association between HLA genetics and functional outcome. Here, we review our current understanding of HLA molecules as the fundamental platform for immune surveillance and responsiveness in health and disease. We evaluate the scope for personalized antigen-specific disease prevention, whereby harnessing HLA-ligand interactions for clinical benefit is becoming a realistic prospect.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/nri.2017.143
Authors
- Publisher:
- Springer Nature
- Journal:
- Nature Reviews Immunology More from this journal
- Volume:
- 18
- Issue:
- 5
- Pages:
- 325-339
- Publication date:
- 2018-01-02
- Acceptance date:
- 2018-01-02
- DOI:
- EISSN:
-
1474-1741
- ISSN:
-
1474-1733
- Pmid:
-
29292391
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:817792
- UUID:
-
uuid:df5c1f16-0429-4776-8a5a-748aa2db3edf
- Local pid:
-
pubs:817792
- Source identifiers:
-
817792
- Deposit date:
-
2019-06-30
- ARK identifier:
Terms of use
- Copyright holder:
- Nature Research
- Copyright date:
- 2018
- Notes:
- © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
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