Journal article icon

Journal article

Assembly of MHC class I molecules analyzed in vitro.

Abstract:

Recent evidence suggests that peptide ligands take part in the assembly of class I molecules in living cells. We now describe a simple system for studying class I assembly in vitro. Detergent extracts of the mutant cells RMA-S and .174, in which class I assembly does not occur spontaneously, will support assembly in vitro when specific peptides are added. Peptides stabilize a conformational change in the class I heavy chain and association with beta 2-microglobulin, at concentrations approxim...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Role:
Author
Expand authors...
Journal:
Cell
Volume:
62
Issue:
2
Pages:
285-295
Publication date:
1990-07-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:df495b79-e387-4e6c-8f44-ee04c92bd449
Source identifiers:
35109
Local pid:
pubs:35109

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP