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Direct ex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection.

Abstract:

The role of intrahepatic lymphocytes in the control of hepatitis C virus (HCV) infection and the pathology associated with it is not understood; most studies of the immunology of this infection use peripheral blood lymphocyte populations. To address this further, we examined in detail the IHL from HCV-infected patients and controls, focusing on the antigen-specific CD8(+) T lymphocyte component. Individual T cells from needle liver biopsies and peripheral blood were isolated from patients wit...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
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Journal:
European journal of immunology
Volume:
31
Issue:
8
Pages:
2388-2394
Publication date:
2001-08-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:df0cfc3c-f6da-4e2a-ab10-2a52458de943
Source identifiers:
29467
Local pid:
pubs:29467

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