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Effects of anacetrapib in patients with atherosclerotic vascular disease

Abstract:

BACKGROUND Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.

METHODS We...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Version of record

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Publisher copy:
10.1056/NEJMoa1706444

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More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Dept of Population Health, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Dept of Population Health, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Dept of Population Health, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Dept of Population Health, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Dept of Population Health, Clinical Trial Service Unit
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Medical Research Council More from this funder
Clinical Research Network More from this funder
Publisher:
Massachusetts Medical Society Publisher's website
Journal:
New England Journal of Medicine Journal website
Publication date:
2017-08-28
Acceptance date:
2017-08-14
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Pubs id:
pubs:729362
URN:
uri:df07e2b2-a291-4296-89a1-0f307517a1d4
UUID:
uuid:df07e2b2-a291-4296-89a1-0f307517a1d4
Local pid:
pubs:729362

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