The beta agonist lung injury trial prevention. A randomized controlled trial.

Journal article

RATIONALE: Experimental studies suggest that pretreatment with β-agonists might prevent acute lung injury (ALI). OBJECTIVES: To determine if in adult patients undergoing elective esophagectomy, perioperative treatment with inhaled β-agonists effects the development of early ALI. METHODS: We conducted a randomized placebo-controlled trial in 12 UK centers (2008-2011). Adult patients undergoing elective esophagectomy were allocated to prerandomized, sequentially numbered treatment packs contain...

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Authors: Perkins, G; Gates, S; Park, D; Gao, F; Knox, C

• Journal: American journal of respiratory and critical care medicine
• Volume: 189
• Issue: 6
• Pages: 674-683
• Publication date: 2014-03-01
• DOI: 10.1164/rccm.201308-1549oc
• EISSN: 1535-4970
• ISSN: 1073-449X
• Language: English
• Keywords: Postoperative Complications; Administration, Inhalation; Perioperative Care; Albuterol; Acute Lung Injury; Female; Adrenergic beta-2 Receptor Agonists; Middle Aged; Male; Intention to Treat Analysis; Treatment Outcome; Drug Administration Schedule; Aged; BALTI-Prevention Collaborators; Logistic Models; Elective Surgical Procedures; Adult; Esophagectomy; Humans