Intracellular Aβ42 Aggregation Leads to Cellular Thermogenesis

Journal article

Brain temperature determines not only an individual's cognitive functionality but also the prognosis and mortality rates of many brain diseases. More specifically, brain temperature not only changes in response to different physiological events like yawning and stretching, but also plays a significant pathophysiological role in a number of neurological and neuropsychiatric illnesses. Here, we have outlined the function of brain hyperthermia in both diseased and healthy states, focusing particularly on the amyloid beta aggregation in Alzheimer's disease

Authors: Chung, CW; Stephens, AD; Konno, T; Ward, E; Avezov, E

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Chemical Society
• Journal: Journal of the American Chemical Society
• Volume: 144
• Issue: 22
• Pages: 10034-10041
• Publication date: 2022-05-26
• DOI: 10.1021/jacs.2c03599
• EISSN: 1520-5126
• ISSN: 0002-7863
• Language: English
• Keywords: Intracellular; Nucleation; Cell; Amyloid (mycology); Thermogenesis; Chemistry; Protein aggregation; Biochemistry; Cell biology; Biophysics