Journal article
Protein Target Highlights in CASP16: Insights From the Structure Providers
- Abstract:
- This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions. While the overall performance of structure prediction methods remains impressive, challenges persist, particularly in modeling rare structural motifs, flexible regions, small molecule interactions, posttranslational modifications, and biologically important interfaces. Addressing these limitations can strengthen the role of structure prediction in complementing experimental efforts and advancing both basic research and biomedical applications.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 10.4MB, Terms of use)
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- Publisher copy:
- 10.1002/prot.70025
Authors
+ U.S. National Science Foundation
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- Funder identifier:
- https://ror.org/021nxhr62
+ National Health and Medical Research Council
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- Funder identifier:
- https://ror.org/011kf5r70
- Publisher:
- Wiley
- Journal:
- Proteins: Structure, Function, and Bioinformatics More from this journal
- Publication date:
- 2025-10-09
- Acceptance date:
- 2025-07-18
- DOI:
- EISSN:
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1097-0134
- ISSN:
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0887-3585
- Language:
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English
- Keywords:
- Pubs id:
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2301130
- Local pid:
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pubs:2301130
- Source identifiers:
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3356278
- Deposit date:
-
2025-10-09
- ARK identifier:
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Terms of use
- Copyright date:
- 2025
- Licence:
- CC Attribution (CC BY)
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