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Dystroglycan function is a novel determinant of tumor growth and behavior in prostate cancer.

Abstract:

BACKGROUND: Dystroglycan is a ubiquitously expressed cell adhesion molecule frequently found to be altered or reduced in adenocarcinomas, however the mechanisms or consequences of dystroglycan loss have not been studied extensively. METHODS: We examined the consequence of overexpression or RNAi depletion of dystroglycan on properties of in vitro growth migration and invasion of LNCaP, PC3, and DU145 prostate cancer cell lines. RESULTS: Using LNCaP cells we observed cell density-dependent chan...

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Publisher copy:
10.1002/pros.22581

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences, Biomedical Research Centre
Role:
Author
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Journal:
The Prostate
Volume:
73
Issue:
4
Pages:
398-408
Publication date:
2013-03-05
DOI:
EISSN:
1097-0045
ISSN:
0270-4137
URN:
uuid:ded0001e-f71b-46ac-9336-01958ae54246
Source identifiers:
352484
Local pid:
pubs:352484

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