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Journal article

Inhibition of 2-oxoglutarate dependent oxygenases.

Abstract:

2-Oxoglutarate (2OG) dependent oxygenases are ubiquitous iron enzymes that couple substrate oxidation to the conversion of 2OG to succinate and carbon dioxide. In humans their roles include collagen biosynthesis, fatty acid metabolism, DNA repair, RNA and chromatin modifications, and hypoxic sensing. Commercial applications of 2OG oxygenase inhibitors began with plant growth retardants, and now extend to a clinically used pharmaceutical compound for cardioprotection. Several 2OG oxygenases ar...

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Publication status:
Published

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Publisher copy:
10.1039/c0cs00203h

Authors

More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemical Society reviews More from this journal
Volume:
40
Issue:
8
Pages:
4364-4397
Publication date:
2011-08-01
DOI:
EISSN:
1460-4744
ISSN:
0306-0012
Language:
English
Keywords:
Pubs id:
pubs:124346
UUID:
uuid:de7f3195-8f20-40b8-9c9a-fcfc8a04fef3
Local pid:
pubs:124346
Source identifiers:
124346
Deposit date:
2012-12-19

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