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Protection of HIV neutralizing aptamers against rectal and vaginal nucleases: implications for RNA-based therapeutics.

Abstract:

RNA-based drugs are an emerging class of therapeutics. They have the potential to regulate proteins, chromatin, as well as bind to specific proteins of interest in the form of aptamers. These aptamers are protected from nuclease attack by chemical modifications that enhance their stability for in vivo usage. However, nucleases are ubiquitous, and as we have yet to characterize the entire human microbiome it is likely that many nucleases are yet to be identified. Any novel, unusual enzymes pre...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.178426

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Cookson, J More by this author
Coventry, VK More by this author
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Journal:
The Journal of biological chemistry
Volume:
286
Issue:
4
Pages:
2526-2535
Publication date:
2011-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:de7db701-1be9-4139-8108-7eef6e2d9d91
Source identifiers:
97291
Local pid:
pubs:97291

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