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MHC class II invariant chain–adjuvanted viral vectored vaccines enhances T cell responses in humans

Abstract:

Strategies to enhance the induction of high magnitude T cell responses through vaccination are urgently needed. Major histocompatibility complex (MHC) class II–associated invariant chain (Ii) plays a critical role in antigen presentation, forming MHC class II peptide complexes for the generation of CD4+ T cell responses. Preclinical studies evaluating the fusion of Ii to antigens encoded in vector delivery systems have shown that this strategy may enhance T cell immune responses to the encode...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Subgroup:
Jenner Institute
Role:
Author
ORCID:
0000-0001-6347-966X
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Role:
Author
ORCID:
0000-0002-0763-6269
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0001-6751-3300
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Contributors

Role:
Contributor
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Translational Medicine Journal website
Volume:
12
Issue:
548
Article number:
eaaz7715
Publication date:
2020-06-17
Acceptance date:
2020-05-26
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Pmid:
32554708
Pubs id:
1114278
Local pid:
pubs:1114278
Language:
English
Keywords:
Format:
Print

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