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An integrated anti-arrhythmic target network of a Chinese medicine compound, Wenxin Keli, revealed by combined machine learning and molecular pathway analysis

Abstract:

Wenxin Keli (WK), a Chinese patent medicine, is known to be effective against cardiac arrhythmias and heart failure. Although a number of electrophysiological findings regarding its therapeutic effect have been reported, the active components and system-level characterizations of the component-target interactions of WK have yet to be elucidated. In the current study, we present the first report of a new protective effect of WK on suppressing anti-arrhythmic-agent-induced arrhythmias. In a mod...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1039/c7mb00003k

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Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Molecular BioSystems Journal website
Volume:
13
Issue:
5
Pages:
1018-1030
Publication date:
2017-03-24
Acceptance date:
2017-03-24
DOI:
EISSN:
1742-2051
ISSN:
1742-206X
Pubs id:
pubs:690319
URN:
uri:de41dbfd-bf1e-4de6-b68f-763f7a59d0ff
UUID:
uuid:de41dbfd-bf1e-4de6-b68f-763f7a59d0ff
Local pid:
pubs:690319
Paper number:
5
Language:
English
Keywords:

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