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Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders

Abstract:
Background There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor. Aims To investigate whether schizophrenia and bipolar disorder polygenic risk scores can distinguish people with broadly defined psychosis and their unaffected relatives from contro... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1192/bjp.2018.89

Authors


Calafato, MS More by this author
Thygesen, JH More by this author
Ranlund, S More by this author
Zartaloudi, E More by this author
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Grant:
Seventh Framework Programme (602450)
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Grant:
NIHR Biomedical Research Centre at University College London
Publisher:
Cambridge University Press Publisher's website
Journal:
British Journal of Psychiatry Journal website
Volume:
213
Issue:
3
Pages:
535-541
Publication date:
2018-08-16
Acceptance date:
2018-03-13
DOI:
EISSN:
1472-1465
ISSN:
0007-1250
Pubs id:
pubs:911658
URN:
uri:de261fca-94da-4049-af00-564e95c05a0b
UUID:
uuid:de261fca-94da-4049-af00-564e95c05a0b
Local pid:
pubs:911658

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