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Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells.

Abstract:

The resistance of mice against Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells was studied. Thymectomized mice were treated with rat monoclonal antibodies against the L3T4 or Lyt-2 molecule to selectively eliminate the respective T-cell subset. In both L3T4+ and Lyt-2+ T-cell-depleted mice, resistance against subsequent infection with M. tuberculosis was markedly impaired compared with that in untreated controls, with L3T4+ T-cell-depleted mi...

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Publication status:
Published

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Authors


Müller, I More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Kaufmann, SH More by this author
Journal:
Infection and immunity
Volume:
55
Issue:
9
Pages:
2037-2041
Publication date:
1987-09-05
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:ddf563a6-f695-4c59-8d42-798101cbd4b1
Source identifiers:
12097
Local pid:
pubs:12097

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