Targeting rheumatoid tenosynovial angiogenesis with cytokine inhibitors.

Journal article

UNLABELLED: Proliferation and invasion of the tenosynovial lining of tendons in patients with rheumatoid arthritis can result in tendon damage and rupture, leading to decreased hand function. Angiogenesis is an important process in rheumatoid joint disease; however, the role of angiogenesis in tendon disease is unknown. Our aim was to determine whether rheumatoid tenosynovial lining could produce angiogenic proteins, and if inhibition of tumor necrosis factor-alpha and interleukin-1 could dec...

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Authors: Jain, A; Kiriakidis, S; Brennan, F; Sandison, A; Paleolog, E

• Publication status: Published
• Journal: Clinical orthopaedics and related research
• Volume: 446
• Issue: 446
• Pages: 268-277
• Publication date: 2006-05-01
• DOI: 10.1097/01.blo.0000205909.89845.f6
• EISSN: 1528-1132
• ISSN: 0009-921X
• Language: English
• Keywords: Treatment Outcome; Female; Humans; Enzyme-Linked Immunosorbent Assay; Tumor Necrosis Factor-alpha; Antibodies, Monoclonal; Neovascularization, Pathologic; Antirheumatic Agents; Middle Aged; Tendons; Male; Arthritis, Rheumatoid; Vascular Endothelial Growth Factor A; Interleukin-1; Adult; Aged, 80 and over; Synovial Membrane; Aged; Cytokines