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Journal article

The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor.

Abstract:

T-cell receptor (TCR) triggering results in a cascade of intracellular tyrosine phosphorylation events that ultimately leads to T-cell activation. It is dependent on changes in the relative activities of membrane-associated tyrosine kinases and phosphatases near the engaged TCR. CD45 and CD148 are transmembrane tyrosine phosphatases with large ectodomains that have activatory and inhibitory effects on TCR triggering. This study investigates whether and how the ectodomains of CD45 and CD148 mo...

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Publication status:
Published

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Authors


Cordoba, SP More by this author
Choudhuri, K More by this author
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Journal:
Blood
Volume:
121
Issue:
21
Pages:
4295-4302
Publication date:
2013-05-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:dd4c5077-b681-49b1-8967-2395897c36e1
Source identifiers:
395070
Local pid:
pubs:395070

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