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Journal article

BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability.

Abstract:

Brain-derived neurotrophic factor (BDNF), via activation of TrkB receptors, mediates vital physiological functions in the brain, ranging from neuronal survival to synaptic plasticity, and has been implicated in the pathophysiology of neurodegenerative disorders. Although transcriptional regulation of the BDNF gene (Bdnf) has been extensively studied, much remains to be understood. We discovered a sequence within Bdnf promoter 4 that binds the basic helix-loop-helix protein BHLHB2 and is a tar...

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Publication status:
Published

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Authors


Copeland, NG More by this author
Jenkins, NA More by this author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
28
Issue:
5
Pages:
1118-1130
Publication date:
2008-01-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:dd4be058-d536-407f-a9f8-46f286f4f9af
Source identifiers:
125237
Local pid:
pubs:125237

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