Journal article : Correspondence

Promises under pressure: the modest predictive power of polygenic risk scores

Abstract:: Comment on a controversial topic in genomics and a response to: Roberts, E., Flaum, N. & Evans, D.G. Clinical implementation of polygenic risk scores. Eur J Hum Genet (2025). https://doi.org/10.1038/s41431-025-01931-9.

Publication status:: Published

Peer review status:: Reviewed (other)

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APA Style

Horton, R., Dunlop, M., McCartney, M., Sud, A., Sullivan, R., Tomlinson, I., Turnbull, C., Houlston, R., & Lucassen, A. (2026). Promises under pressure: the modest predictive power of polygenic risk scores. European Journal of Human Genetics.

MLA Style

Horton, R, et al. “Promises under Pressure: the Modest Predictive Power of Polygenic Risk Scores.” European Journal of Human Genetics, 2026.

Chicago Style

Horton, R, M Dunlop, M McCartney, et al. 2026. “Promises under Pressure: the Modest Predictive Power of Polygenic Risk Scores.” European Journal of Human Genetics.
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Publisher copy:: 10.1038/s41431-025-01996-6

Authors

+ Horton, R More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Centre for Human Genetics
Role:: Author
ORCID:: 0000-0001-6080-6354

+ Dunlop, M More by this author

Role:: Author
ORCID:: 0000-0002-3033-5851

+ McCartney, M More by this author

Role:: Author

+ Sud, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: NDM Immuno-Oncology
Role:: Author
ORCID:: 0000-0002-6133-0164

+ Sullivan, R More by this author

Role:: Author

More authors...

Publisher:: Springer Nature
Journal:: European Journal of Human Genetics More from this journal
Publication date:: 2026-01-08
Acceptance date:: 2025-11-12
DOI:: 10.1038/s41431-025-01996-6
EISSN:: 1476-5438
ISSN:: 1018-4813

Language:: English
Subtype:: Correspondence
Pubs id:: 2357173
UUID:: uuid_dd418584-2ba5-4103-a4fd-642ed0f8b867
Local pid:: pubs:2357173
Deposit date:: 2026-01-08
ARK identifier:: ark:/29072/ora_dd4185842ba54103a4fd642ed0f8b867

Terms of use

Copyright holder:: Horton et al
Copyright date:: 2026
Rights statement:: © 2026, The Author(s), under exclusive licence to European Society of Human Genetics

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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