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Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion.

Abstract:

Type IIB receptor protein tyrosine phosphatases (RPTPs) are bi-functional cell surface molecules. Their ectodomains mediate stable, homophilic, cell-adhesive interactions, whereas the intracellular catalytic regions can modulate the phosphorylation state of cadherin/catenin complexes. We describe a systematic investigation of the cell-adhesive properties of the extracellular region of RPTPmu, a prototypical type IIB RPTP. The crystal structure of a construct comprising its N-terminal MAM (mep...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7600974

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
The EMBO journal
Volume:
25
Issue:
4
Pages:
701-712
Publication date:
2006-02-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:dcfecb03-1ec3-4fe1-ab62-4c6df8436aa5
Source identifiers:
30077
Local pid:
pubs:30077

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