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Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis.

Abstract:

Schizophrenia is characterized by altered prefrontal activity and elevated striatal dopaminergic function. To investigate the relationship between these abnormalities in the prodromal phase of the illness, we combined functional Magnetic Resonance Imaging and (18)F-Dopa Positron Emission Tomography. When performing a verbal fluency task, subjects with an At-Risk Mental State showed greater activation in the inferior frontal cortex than controls. Striatal dopamine function was greater in the A...

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Publisher copy:
10.1038/mp.2009.108

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Molecular psychiatry
Volume:
16
Issue:
1
Pages:
67-75
Publication date:
2011-01-05
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
URN:
uuid:dcf7b6ae-3e34-4ad2-8b30-dcf7b89e2fd7
Source identifiers:
403430
Local pid:
pubs:403430

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