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Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.

Abstract:

A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so their delineation currently requires integration of diverse phenotypic data from large studies to ensure robust meta-analyses. We have designed a gene-centric 50 K single nucleotide polymorphism (SNP) ...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0003583

Authors


Keating, BJ More by this author
Tischfield, S More by this author
Murray, SS More by this author
Bhangale, T More by this author
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Journal:
PloS one
Volume:
3
Issue:
10
Pages:
e3583
Publication date:
2008
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:dce65057-3e93-49d9-a71f-57a75c742416
Source identifiers:
66191
Local pid:
pubs:66191

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