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Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes: A Pooled Analysis of 9 Trials.

Abstract:

Thrombolytic therapy with intravenous alteplase within 4.5 hours of ischemic stroke onset increases the overall likelihood of an excellent outcome (no, or nondisabling, symptoms). Any improvement in functional outcome distribution has value, and herein we provide an assessment of the effect of alteplase on the distribution of the functional level by treatment delay, age, and stroke severity.Prespecified pooled analysis of 6756 patients from 9 randomized trials comparing alteplase versus place...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1161/STROKEAHA.116.013644

Authors


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Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Role:
Author
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Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Role:
Author
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Grant:
Core funding to Clinical Trial Service Unit and Epidemiological Studies Unit at the University of Oxford
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Grant:
Core funding to Clinical Trial Service Unit and Epidemiological Studies Unit at the University of Oxford
University of Glasgow More from this funder
University of Edinburgh More from this funder
Publisher:
American Heart Association Publisher's website
Journal:
Stroke Journal website
Volume:
47
Issue:
9
Pages:
2373-2379
Publication date:
2016-08-09
Acceptance date:
2016-07-01
DOI:
EISSN:
1524-4628
ISSN:
0039-2499
Pubs id:
pubs:638490
URN:
uri:dcd5a027-b20c-4a32-bf81-e7516f5910e9
UUID:
uuid:dcd5a027-b20c-4a32-bf81-e7516f5910e9
Local pid:
pubs:638490
Paper number:
9

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